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Recombinant mouse RAPSN protein

CAT: 0112-ATGP2405-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2405-500Size:500 µg
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Description
43 kDa receptor-associated protein of the synapse, also known as RAPSN, is expressed in the postsynaptic membrane of skeletal muscle. RAPSN is required for the clustering of nicotinic acetylcholine receptors (nAChR) . It self-associates through at least two of its seven tetra-tricopeptide repeats (TPRs) . RAPSN interacts with the large intracellular domain of the nAChR a subunit through the hydrophobic surface of the coiled-coil domain. This protein modifies trafficking of AChR within the cell. Overexpression inhibits agrin-induced AChR clustering pathway. Recombinant human RAPSN protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Name Alternative
43 kDa receptor-associated protein of the synapse, 43kDa, Nraps, Raps, rapsyn
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
48.8 kDa (435aa)
Additionnal Information
RAPSN, 43 kDa receptor-associated protein of the synapse, 43kDa, Nraps, Raps, rapsyn, ATGP2405-10 µg, ATGP2405-20 µg, ATGP2405-50 µg, ATGP2405-100 µg, ATGP2405-250 µg, ATGP2405-500 µg, ATGP2405-1 mg, ATGP2405-10, ATGP2405-20, ATGP2405-50, ATGP2405-100, ATGP2405-250, ATGP2405-500, ATGP2405-1
References & Citations
Maimone M M., et al. (1999) Mol Cell Neurosci. 14:340-354.; ; Han H., et al. (1999) J Neurocytol. 28:763-775;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea
Scientific Category
Neuroscience
NCBI Accession Number
NP_033049
Uniprot Accession Number
P12672
Species
Mouse
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGQDQTK QQIEKGLQLY QSNQTEKALQ VWMKVLEKGS DLVGRFRVLG CLVTAHSEMG RYKEMLKFAV VQIDTARGLE DADFLLESYL NLARSNEKLC EFHKTISYCK TCLGLPGTRA GAQLGGQVSL SMGNAFLGLS LFQKALESFE KALRYAHNND DTMLECRVCC SLGSFYAQVK DYEKALFFPC KAAELVNDYG KGWSLKYRAM SQYHMAVAYR LLGHLGSAME CCEESMKIAL QHGDRPLQAL CLLCFADIHR SRGDLETAFP RYDSAMSIMT EIGNRLGQVH VLLGVAKCWM ARKVQDKALD AIEKAQDLAE EVGNKLSQLK LHCLSESIYR SKGLQRELRT HVVRFHECVE ETELYCGLCG ESIGERNSRL QALPCSHIFH LRCLQNNGTR SCPNCRRSSM KPGFV

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