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Recombinant human CNTFR alpha protein

CAT: 0112-ATGP3830-250Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3830-250Size:250 µg
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Description
CNTFR, also known as ciliary neurotrophic factor receptor subunit alpha preproprotein, is expressed in glial cells within the central and peripheral nervous systems. It stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types such as sensory, sympathetic, ciliary and motor neurons. This protein has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6. Also, it possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage. It activates downstream signaling molecules such as STAT-3 in areas of the hypothalamus which regulate food intake. Recombinant human CNTFR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques
Product Name Alternative
Ciliary neurotrophic factor receptor subunit alpha, CNTFR, CNTFR-alpha, ciliary neurotrophic factor receptor
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
36.9 kDa (329aa)
Additionnal Information
CNTF R a, Ciliary neurotrophic factor receptor subunit alpha, CNTFR, CNTFR-alpha, ciliary neurotrophic factor receptor, ATGP3830-10 µg, ATGP3830-20 µg, ATGP3830-50 µg, ATGP3830-100 µg, ATGP3830-250 µg, ATGP3830-500 µg, ATGP3830-1 mg, ATGP3830-10, ATGP3830-20, ATGP3830-50, ATGP3830-100, ATGP3830-250, ATGP3830-500, ATGP3830-1
References & Citations
Davis S., et al. (1991) Science. 253:59-63.; ; Sleeman MW., et al. (2000) Pharm Acta Helv. 74:265-272
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_001833
Uniprot Accession Number
P26992
Species
Human
N Terminal Sequence
Ala
AA Sequence
ADPQRHSPQE APHVQYERLG SDVTLPCGTA NWDAAVTWRV NGTDLAPDLL NGSQLVLHGL ELGHSGLYAC FHRDSWHLRH QVLLHVGLPP REPVLSCRSN TYPKGFYCSW HLPTPTYIPN TFNVTVLHGS KIMVCEKDPA LKNRCHIRYM HLFSTIKYKV SISVSNALGH NATAITFDEF TIVKPDPPEN VVARPVPSNP RRLEVTWQTP STWPDPESFP LKFFLRYRPL ILDQWQHVEL SDGTAHTITD AYAGKEYIIQ VAAKDNEIGT WSDWSVAAHA TPWTEEPRHL TTEAQAAETT TSTTSSLAPP PTTKICDPGE LGSHHHHHH

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