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Recombinant human CD8 alpha protein

CAT: 0112-ATGP3901-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3901-100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD8 alpha, also known as T-cell surface glycoprotein CD8 alpha chain isoform 1, is a member of integralmembrane glycoprotein that plays an essential role in the immune response and serves multiple functions inresponses. It interacts with the T-cell receptor and the MHC class I proteins presented by antigen presentingcells. Homodimers of this protein at the cell surface provides a survival mechanism allowing conjugation and lysisof multiple target cells in NK-cells. Recombinant human CD8 alpha, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
CD8A, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, MAL, CD8, Leu2, p32, T-cell surface glycoprotein CD8 alpha chain isoform 1
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
18.7 kDa (170aa)
Additionnal Information
CD8 a, ATGP3901-10 µg, ATGP3901-20 µg, ATGP3901-50 µg, ATGP3901-100 µg, ATGP3901-250 µg, ATGP3901-500 µg, ATGP3901-1 mg, ATGP3901-10, ATGP3901-20, ATGP3901-50, ATGP3901-100, ATGP3901-250, ATGP3901-500, ATGP3901-1
References & Citations
Harland KL., et al. (2014) Nat Commun. 5:3547.; ; Chen S., et al. (2019) J Cancer. 10:697-707.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001759
Uniprot Accession Number
P01732
Species
Human
N Terminal Sequence
Ala
AA Sequence
SQFRVSP LDRTWNLGET VELKCQVLLS NPTSGCSWLF QPRGAAASPT FLLYLSQNKP KAAEGLDTQR FSGKRLGDTF VLTLSDFRRE NEGYYFCSAL SNSIMYFSHF VPVFLPAKPT TTPAPRPPTP APTIASQPLS LRPEACRPAA GGAVHTRGLD FACD

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