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Recombinant human DPH2 protein

CAT: 0112-ATGP3582-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3582-010Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DPH2, also known as diphthamide biosynthesis protein 2, is a homodimer and each of its monomers can bind a [4Fe-4S] cluster. It is the target of ADP ribosylating diphtheria toxin (DT) and Pseudomonas exotoxin A (PE) . It was identified by its ability to complement a diphthamide mutant strain, and thus functions in diphthamide biosynthesis. Its loss pre-activates NF-kB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor. Recombinant human DPH2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
Diphthamide biosynthesis protein 2, DPH2, DPH2L2
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
53.1 kDa (497aa)
Additionnal Information
DPH2, Diphthamide biosynthesis protein 2, DPH2, DPH2L2, ATGP3582-10 µg, ATGP3582-20 µg, ATGP3582-50 µg, ATGP3582-100 µg, ATGP3582-250 µg, ATGP3582-500 µg, ATGP3582-1 mg, ATGP3582-10, ATGP3582-20, ATGP3582-50, ATGP3582-100, ATGP3582-250, ATGP3582-500, ATGP3582-1
References & Citations
Zhang Y., et al. (2010) Nature. 465:891-896.; ; Mattheakis LC., et al. (1993) Gene. 132:149-154.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 1mM DTT, 20% glycerol
Scientific Category
Cell Cycle
NCBI Accession Number
NP_001375
Uniprot Accession Number
Q9BQC3
Species
Human
N Terminal Sequence
Met1

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