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Recombinant human PDIA6 protein

CAT: 0112-ATGP3139-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3139-020Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDIA6 is a member of the protein disulfide isomerase (PDI) . PDI is an enzyme in the endoplasmic reticulum in eukaryotes or periplasmic space of prokaryotes that catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. PDIA6 function as a chaperone that inhibits aggregation of misfolded proteins. It plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Recombinant human PDIA6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Specifications
Specific activity > 20 A650/cm/min/mg. Enzymatic activity was confirmed by measuring the aggregation of insulin in the presence of DTT.
Product Name Alternative
Protein disulfide-isomerase A6, ERP5, P5, TXNDC7
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Enzyme Activity
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Bioactivity
Specific activity > 10 A650/cm/min/mg. Enzymatic activity was confirmed by measuring the aggregation of insulin in the presence of DTT.
Molecular Weight
48.5 kDa (442aa) confirmed by MALDI-TOF
Additionnal Information
PDIA6, Protein disulfide-isomerase A6, ERP5, P5, TXNDC7, ATGP3139-10 µg, ATGP3139-20 µg, ATGP3139-50 µg, ATGP3139-100 µg, ATGP3139-250 µg, ATGP3139-500 µg, ATGP3139-1 mg, ATGP3139-10, ATGP3139-20, ATGP3139-50, ATGP3139-100, ATGP3139-250, ATGP3139-500, ATGP3139-1
References & Citations
Jordan P.A., et al. (2005) Blood. 105:1500-1507; ; Kikuchi M., et al. (2002) J. Biochem. 132:451-455
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing, 50 mM NaCl, 2mM DTT and 10% glycerol
Scientific Category
Heat Shock Proteins
NCBI Accession Number
NP_005733
Uniprot Accession Number
Q15084
Species
Human
AA Sequence
LYSSSDDVI ELTPSNFNRE VIQSDSLWLV EFYAPWCGHC QRLTPEWKKA ATALKDVVKV GAVDADKHHS LGGQYGVQGF PTIKIFGSNK NRPEDYQGGR TGEAIVDAAL SALRQLVKDR LGGRSGGYSS GKQGRSDSSS KKDVIELTDD SFDKNVLDSE DVWMVEFYAP WCGHCKNLEP EWAAAASEVK EQTKGKVKLA AVDATVNQVL ASRYGIRGFP TIKIFQKGES PVDYDGGRTR SDIVSRALDL FSDNAPPPEL LEIINEDIAK RTCEEHQLCV VAVLPHILDT GAAGRNSYLE VLLKLADKYK KKMWGWLWTE AGAQSELETA LGIGGFGYPA MAAINARKMK FALLKGSFSE QGINEFLREL SFGRGSTAPV GGGAFPTIVE REPWDGRDGE LPVEDDIDLS DVELDDLGKD EL

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