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Recombinant human PPM1D protein

CAT: 0112-ATGP2992-250Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2992-250Size:250 µg
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Description
PPM1D also known as Protein phosphatase 1D magnesium-dependent, delta isoform. This protein is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. Recombinant human PPM1D, fused to His-tag at N-terminus, was expressed in E. coli.
Product Name Alternative
Protein phosphatase 1D magnesium-dependent delta isoform, Protein phosphatase 1D magnesium-dependent, delta isoform, PP2C-DELTA, WIP1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
33.2 kDa (299aa)
Additionnal Information
PPM1D, ATGP2992-10 µg, ATGP2992-20 µg, ATGP2992-50 µg, ATGP2992-100 µg, ATGP2992-250 µg, ATGP2992-500 µg, ATGP2992-1 mg, ATGP2992-10, ATGP2992-20, ATGP2992-50, ATGP2992-100, ATGP2992-250, ATGP2992-500, ATGP2992-1
References & Citations
Fiscella M., et al. (1997) Proc Natl Acad Sci u S A, 94 (12) : 6048-53.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
AAH33893
Uniprot Accession Number
Q8NEA7
Species
Human
AA Sequence
VAFFAVCDG HGGREAAQFA REHFWGFIKK QKGFTSSEPA KVCAAIRKGF LACHLAMWKK LAEWPKTMTG LPSTSGTTAS VVIIRGMKMY VAHVGDSGVV LGIQDDPKDD FVRAVEVTQD HKPELPKERE RIEGLGGSVM NKSGVNRVVW KRPRLTHNGP VRRSTVIDQI PFLAVARALG DLWSYDFFSG EFVVSPEPDT SVHTLDPQKH KYIILGSDGL WNMIPPQDAI SMCQDQEEKK YLMGEHGQSC AKMLVNRALG RWRQRMLRAD NTSAIVICI

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