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Recombinant human B-Raf protein

CAT: 0112-ATGP2924-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2924-020Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BRAF belongs to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. Recombinant human BRAF protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Name Alternative
Serine/threonine-protein kinase B-raf, Serine/threonine-protein kinase B-raf, B-RAF1, BRAF1, NS7, RAFB1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
40.6 kDa (360aa)
Additionnal Information
B-Raf, Serine/threonine-protein kinase B-raf, Serine/threonine-protein kinase B-raf, B-RAF1, BRAF1, NS7, RAFB1, ATGP2924-10 µg, ATGP2924-20 µg, ATGP2924-50 µg, ATGP2924-100 µg, ATGP2924-250 µg, ATGP2924-500 µg, ATGP2924-1 mg, ATGP2924-10, ATGP2924-20, ATGP2924-50, ATGP2924-100, ATGP2924-250, ATGP2924-500, ATGP2924-1
References & Citations
Brennan D.F., et al. (2011) Nature 472:366-369
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Apoptosis
NCBI Accession Number
NP_004324.2
Uniprot Accession Number
P15056
Species
Human
AA Sequence
SEDRN RMKTLGRRDS SDDWEIPDGQ ITVGQRIGSG SFGTVYKGKW HGDVAVKMLN VTAPTPQQLQ AFKNEVGVLR KTRHVNILLF MGYSTKPQLA IVTQWCEGSS LYHHLHIIET KFEMIKLIDI ARQTAQGMDY LHAKSIIHRD LKSNNIFLHE DLTVKIGDFG LATVKSRWSG SHQFEQLSGS ILWMAPEVIR MQDKNPYSFQ SDVYAFGIVL YELMTGQLPY SNINNRDQII FMVGRGYLSP DLSKVRSNCP KAMKRLMAEC LKKKRDERPL FPQILASIEL LARSLPKIHR SASEPSLNRA GFQTEDFSLY ACASPKTPIQ AGGYGAFPVH

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