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Recombinant human VAP-B protein

CAT: 0112-ATGP0800-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0800-100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VAPB, also known as vesicle-associated membrane protein (VAMP) -associated protein B, is a type IV transmembrane protein and member of the VAP family of proteins. This protein may play a role in vesicle trafficking. It is found in plasma and intracellular vesicle membranes as a homodimer and heterodimer with VAPA, and interacts with VAMP1 and VAMP2. Defects in VAPB are a cause of amyotrophic lateral sclerosis type 8 and spinal muscular atrophy autosomal dominant Finkel type. Recombinant human VAPB protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Name Alternative
Vesicle-associated membrane protein-associated protein B/C, ALS8, VAMP-B, VAMP-C, VAP-B, VAP-C
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
27.1 kDa (242aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
VAP-B, Vesicle-associated membrane protein-associated protein B/C, ALS8, VAMP-B, VAMP-C, VAP-B, VAP-C, ATGP0800-10 µg, ATGP0800-20 µg, ATGP0800-50 µg, ATGP0800-100 µg, ATGP0800-250 µg, ATGP0800-500 µg, ATGP0800-1 mg, ATGP0800-10, ATGP0800-20, ATGP0800-50, ATGP0800-100, ATGP0800-250, ATGP0800-500, ATGP0800-1
References & Citations
Nishimura AL, et al. (2004), Am J Hum Genet., 75 (5) :822-31.; ; Hamamoto I., et al. (2005) . J Virol., 79 (21) :13473-82.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_004729
Uniprot Accession Number
O95292
Species
Human
AA Sequence
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGI IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS DMEAVWKEAK PEDLMDSKLR CVFELPAEND KPHDVEINKI ISTTASKTET PIVSKSLSSS LDDTEVKKVM EECKRLQGEV QRLREENKQF KEEDGLRMRK TVQSNSPISA LAPTGKEEGL ST

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