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Recombinant human PELI2 protein

CAT: 0112-ATGP2792-050Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2792-050Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PELI2 is an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. This protein is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. PELI2 may be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. It can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Recombinant human PELI2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
E3 ubiquitin-protein ligase pellino homolog 2, PELI2 - pellino E3, Pellino-2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
48.8 kDa (443aa) confirmed by MALDI-TOF
Additionnal Information
PELI2, E3 ubiquitin-protein ligase pellino homolog 2, PELI2-pellino E3, Pellino-2, ATGP2792-10 µg, ATGP2792-20 µg, ATGP2792-50 µg, ATGP2792-100 µg, ATGP2792-250 µg, ATGP2792-500 µg, ATGP2792-1 mg, ATGP2792-10, ATGP2792-20, ATGP2792-50, ATGP2792-100, ATGP2792-250, ATGP2792-500, ATGP2792-1
References & Citations
Jensen L.E., et al (2003) . FEBS Lett. 545:199-202; ; Strelow A., et al (2003) . FEBS Lett. 547:157-161
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_067078
Uniprot Accession Number
Q9HAT8
Species
Human
AA Sequence
MFSPGQE EHCAPNKEPV KYGELVVLGY NGALPNGDRG RRKSRFALYK RPKANGVKPS TVHVISTPQA SKAISCKGQH SISYTLSRNQ TVVVEYTHDK DTDMFQVGRS TESPIDFVVT DTISGSQNTD EAQITQSTIS RFACRIVCDR NEPYTARIFA AGFDSSKNIF LGEKAAKWKN PDGHMDGLTT NGVLVMHPRG GFTEESQPGV WREISVCGDV YTLRETRSAQ QRGKLVESET NVLQDGSLID LCGATLLWRT ADGLFHTPTQ KHIEALRQEI NAARPQCPVG LNTLAFPSIN RKEVVEEKQP WAYLSCGHVH GYHNWGHRSD TEANERECPM CRTVGPYVPL WLGCEAGFYV DAGPPTHAFT PCGHVCSEKS AKYWSQIPLP HGTHAFHAAC PFCATQLVGE QNCIKLIFQG PID

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