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Recombinant human COA4 protein

CAT: 0112-ATGP2716-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2716-010Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cytochrome c oxidase assembly factor 4 homolog, mitochondrial, also known as COA4, is the last enzyme of the mitochondrial respiratory chain, is a very complicated process and requires the assistance of a large number of accessory factors. It is essential for oxidative phosphorylation and comprises multiple complexes, including cytochrome c oxidase, assembled in macromolecular supercomplexes. Defects in COX4 assembly alter cellular respiration and produce severe human encephalomyopathies. Recombinant human COA4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Cytochrome c oxidase assembly factor 4 homolog mitochondrial, Cytochrome c oxidase assembly factor 4 homolog, mitochondrial, CHCHD8, CMC3, E2IG2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
12.5 kDa (110aa) confirmed by MALDI-TOF
Additionnal Information
COA4, Cytochrome c oxidase assembly factor 4 homolog mitochondrial, Cytochrome c oxidase assembly factor 4 homolog, mitochondrial, CHCHD8, CMC3, E2IG2, ATGP2716-10 µg, ATGP2716-20 µg, ATGP2716-50 µg, ATGP2716-100 µg, ATGP2716-250 µg, ATGP2716-500 µg, ATGP2716-1 mg, ATGP2716-10, ATGP2716-20, ATGP2716-50, ATGP2716-100, ATGP2716-250, ATGP2716-500, ATGP2716-1
References & Citations
Diaz F., et al. (2012) Hum Mol Genet. 1 (23) : 5066-77.; ; Huigsloot M., et al. (2011) Am J Hum Genet. 8 (4) : 488-93.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Other
NCBI Accession Number
NP_057649
Uniprot Accession Number
Q9NYJ1
Species
Human
AA Sequence
MSTSVPQ GHTWTQRVKK DDEEEDPLDQ LISRSGCAAS HFAVQECMAQ HQDWRQCQPQ VQAFKDCMSE QQARRQEELQ RRQEQAGAHH

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