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Recombinant human PTGR2 protein

CAT: 0112-ATGP1505-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1505-010Size:10 µg
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Description
PTGR2 belongs to the medium-chain dehydrogenase/reductase superfamily. PTGR2 catalyzes an NADPH-dependent reduction of the conjugated alpha, beta-unsaturated double bond of 15-keto-PGE (2), a key step in terminal inactivation of prostaglandins and suppression of PPARgamma-mediated adipocyte differentiation. Selective inhibition of PTGR2 may contribute to the improvement of insulin sensitivity with fewer side effects. Recombinant human PTGR2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Prostaglandin reductase 2, PGR2, ZADH1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
41 kDa (375aa) confirmed by MALDI-TOF
Additionnal Information
PTGR2, Prostaglandin reductase 2, PGR2, ZADH1, ATGP1505-10 µg, ATGP1505-20 µg, ATGP1505-50 µg, ATGP1505-100 µg, ATGP1505-250 µg, ATGP1505-500 µg, ATGP1505-1 mg, ATGP1505-10, ATGP1505-20, ATGP1505-50, ATGP1505-100, ATGP1505-250, ATGP1505-500, ATGP1505-1
References & Citations
Wu Y.H., et al. (2008) Structure 16:1714-1723; ; Auld, D.S. et al. (2008) Cell. Mol. Life Sci. 65: 3961-3970.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 50 mM NaCl
Scientific Category
Redox Proteins
NCBI Accession Number
NP_689657.1
Uniprot Accession Number
Q8N8N7
Species
Human
AA Sequence
MIVQRV VLNSRPGKNG NPVAENFRME EVYLPDNINE GQVQVRTLYL SVDPYMRCRM NEDTGTDYIT PWQLSQVVDG GGIGIIEESK HTNLTKGDFV TSFYWPWQTK VILDGNSLEK VDPQLVDGHL SYFLGAIGMP GLTSLIGIQE KGHITAGSNK TMVVSGAAGA CGSVAGQIGH FLGCSRVVGI CGTHEKCILL TSELGFDAAI NYKKDNVAEQ LRESCPAGVD VYFDNVGGNI SDTVISQMNE NSHIILCGQI SQYNKDVPYP PPLSPAIEAI QKERNITRER FLVLNYKDKF EPGILQLSQW FKEGKLKIKE TVINGLENMG AAFQSMMTGG NIGKQIVCIS EEISL

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