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Recombinant human DCTPP1 protein

CAT: 0112-ATGP1381-250Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1381-250Size:250 µg
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Description
DCTPP1, also known as dCTP pyrophosphatase 1, contains an epilepsy-associated repeat (EAR) domain that is predicted to participate in protein-protein interactions, most likely involved in ligand recognition. This protein functions to hydrolyze abnormal nucleotide triphosphates (NTPs) in cancer cells that, if unregulated, could be incorporated into nascent DNA or RNA. Recombinant human DCTPP1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Name Alternative
Deoxycytidine-triphosphatase 1, dCTPase 1, dCTP pyrophosphatase 1, CDA03, RS21C6, XTP3TPA
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
21.2 kDa (194aa) confirmed by MALDI-TOF
Additionnal Information
DCTPP1, dCTP pyrophosphatase 1, CDA03, RS21C6, XTP3TPA, ATGP1381-10 µg, ATGP1381-20 µg, ATGP1381-50 µg, ATGP1381-100 µg, ATGP1381-250 µg, ATGP1381-500 µg, ATGP1381-1 mg, ATGP1381-10, ATGP1381-20, ATGP1381-50, ATGP1381-100, ATGP1381-250, ATGP1381-500, ATGP1381-1
References & Citations
Moroz O.V. et al. (2005) J. Mol. Biol. 347: 243-255.; ; Rual J.F. et al. (2005) Nature 437:1173-1178.
Other References
Kawamura T, et al. Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. (Sci Rep. 2016) {https://pubmed.ncbi.nlm.nih.gov/27210421/}
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_077001
Uniprot Accession Number
Q9H773
Species
Human
AA Sequence
MSVAGG EIRGDTGGED TAAPGRFSFS PEPTLEDIRR LHAEFAAERD WEQFHQPRNL LLALVGEVGE LAELFQWKTD GEPGPQGWSP RERAALQEEL SDVLIYLVAL AARCRVDLPL AVLSKMDINR RRYPAHLARS SSRKYTELPH GAISEDQAVG PADIPCDSTG QTST

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