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Recombinant human CHMP4A protein

CAT: 0112-ATGP1376-050Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1376-050Size:50 µg
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Description
CHMP4A (Chromatin-modifying protein 4a) belongs to the SNF7 family and functions as chromatin-modifying proteins. It probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. Also during HIV-1 infection, the virus uses the ESCRT-III complex to mediate budding and exocytosis of viral proteins via the association of CHMP4 and a protein recruited by HIV-1 p6, which is present in viral Gag assembly and budding. CHMP4A expressed at higher level in heart, kidney, liver and skeletal muscle. Recombinant human CHMP4A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Charged multivesicular body protein 4A, Chromatin-modifying protein 4a, CHMP4a, SNF7 homolog associated with Alix-2, SNF7-1, hSnf-1, Vacuolar protein sorting-associated protein 32-1, Vps32-1, hVps32-1, HSPC134, VPS32A
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
31.9kDa (285aa) confirmed by MALDI-TOF
Additionnal Information
CHMP4A, chromatin modifying protein 4A, CHMP4, CHMP4B, HSPC134, SHAX2, SNF7, SNF7-1, VPS32-1, VPS32A, ATGP1376-10 µg, ATGP1376-20 µg, ATGP1376-50 µg, ATGP1376-100 µg, ATGP1376-250 µg, ATGP1376-500 µg, ATGP1376-1 mg, ATGP1376-10, ATGP1376-20, ATGP1376-50, ATGP1376-100, ATGP1376-250, ATGP1376-500, ATGP1376-1
References & Citations
Katoh K., et al. (2004) Arch. Biochem. Biophys. 421:159-165; ; Strack B., et al (2003) Cell 114:689-699
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 50% glycerol, 200 mM NaCl, 0.1mM PMSF, 1mM EDTA
Scientific Category
Metabolism
NCBI Accession Number
NP_054888
Uniprot Accession Number
Q9BY43
Species
Human
AA Sequence
MSRRRPEDGL GKAGPCVMRH HPPRSKAEVW RTLRGGGGRG ELAMSGLGRL FGKGKKEKGP TPEEAIQKLK ETEKILIKKQ EFLEQKIQQE LQTAKKYGTK NKRAALQALR RKKRFEQQLA QTDGTLSTLE FQREAIENAT TNAEVLRTME LAAQSMKKAY QDMDIDKVDE LMTDITEQQE VAQQISDAIS RPMGFGDDVD EDELLEELEE LEQEELAQEL LNVGDKEEEP SVKLPSVPST HLPAGPAPKV DEDEEALKQL AEWVS

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