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Recombinant human SUFU protein

CAT: 0112-ATGP1221-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1221-020Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SuFu (Suppressor of fused homolog) belongs to the SuFu family. This protein is negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. SuFu has been shown to interact with GLI1, GLI3 and PEX26. Recombinant human SuFu protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Suppressor of fused homolog, PRO1280, SuFuH, SuFuXL
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
56.1 kDa (504aa)
Additionnal Information
SUFU, suppressor of fused homolog, PRO1280, SuFuH, SuFuXL, ATGP1221-10 µg, ATGP1221-20 µg, ATGP1221-50 µg, ATGP1221-100 µg, ATGP1221-250 µg, ATGP1221-500 µg, ATGP1221-1 mg, ATGP1221-10, ATGP1221-20, ATGP1221-50, ATGP1221-100, ATGP1221-250, ATGP1221-500, ATGP1221-1
References & Citations
Dunaeva M, et al. (2003) J. Biol. Chem. 278 (7) : 5116-22.; ; Murone M., et al. (2000) Nat. Cell Biol. 2:310-312
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_057253
Uniprot Accession Number
Q9UMX1
Species
Human
AA Sequence
MAELRPSGAP GPTAPPAPGP TAPPAFASLF PPGLHAIYGE CRRLYPDQPN PLQVTAIVKY WLGGPDPLDY VSMYRNVGSP SANIPEHWHY ISFGLSDLYG DNRVHEFTGT DGPSGFGFEL TFRLKRETGE SAPPTWPAEL MQGLARYVFQ SENTFCSGDH VSWHSPLDNS ESRIQHMLLT EDPQMQPVQT PFGVVTFLQI VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR GETIFEIDPH LQERVDKGIE TDGSNLSGVS AKCAWDDLSR PPEDDEDSRS ICIGTQPRRL SGKDTEQIRE TLRRGLEINS KPVLPPINPQ RQNGLAHDRA PSRKDSLESD SSTAIIPHEL IRTRQLESVH LKFNQESGAL IPLCLRGRLL HGRHFTYKSI TGDMAITFVS TGVEGAFATE EHPYAAHGPW LQILLTEEFV EKMLEDLEDL TSPEEFKLPK EYSWPEKKLK VSILPDVVFD SPLH

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