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Recombinant human POMC protein

CAT: 0112-ATGP1088-250Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1088-250Size:250 µg
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Description
Pro-opiomelanocortin preproprotein, also known as POMC, a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. It regulates the corticosteroid production in the adrenal cortex. Also, POMC is cleaved into ten hormone chains named NPP, gamma-MSH, ACTH, alpha-MSH, CLIP, Lipotropin beta, Lipotropin gamma, beta-MSH, beta endorphin and Met-enkephalin. Defects in the gene that encodes POMC are the cause of POMC deficiency, which is characterized by red hair and adrenal insufficiency. Recombinant human POMC protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Pro-opiomelanocortin preproprotein, ACTH, CLIP, LPH, MSH, NPP, POC
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
28.9 kDa (262aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
POMC, ATGP1088-10 µg, ATGP1088-20 µg, ATGP1088-50 µg, ATGP1088-100 µg, ATGP1088-250 µg, ATGP1088-500 µg, ATGP1088-1 mg, ATGP1088-10, ATGP1088-20, ATGP1088-50, ATGP1088-100, ATGP1088-250, ATGP1088-500, ATGP1088-1
References & Citations
Grassel S., et al. (2009) Arthritis Rheum. 60:3017-3027.; ; Belgardt B F., et al. (1992) J Physiol. 587:5305-5314.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.5) containing 1mM DTT, 50% glycerol, 0.2M NaCl, 0.1mM PMSF, 100 mM Imidazole
Scientific Category
Metabolism
NCBI Accession Number
NP_001030333
Uniprot Accession Number
P01189
Species
Human
AA Sequence
WCLESSQCQ DLTTESNLLE CIRACKPDLS AETPMFPGNG DEQPLTENPR KYVMGHFRWD RFGRRNSSSS GSSGAGQKRE DVSAGEDCGP LPEGGPEPRS DGAKPGPREG KRSYSMEHFR WGKPVGKKRR PVKVYPNGAE DESAEAFPLE FKRELTGQRL REGDGPDGPA DDGAGAQADL EHSLLVAAEK KDEGPYRMEH FRWGSPPKDK RYGGFMTSEK SQTPLVTLFK NAIIKNAYKK GE

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