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Recombinant human KDSR protein

CAT: 0112-ATGP0948-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0948-100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KDSR, also known as 3-ketodihydrosphingosine reductase, is a 332 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum (ER) and belongs to the short-chain dehydrogenases/reductases (SDR) family. KDSR is a secreted protein which is weakly expressed in hematopoietic tissue. Also this protein catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS) Recombinant human KDSR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
3-ketodihydrosphingosine reductase, DHSR, FVT1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
29.0 kDa (266aa) confirmed by MALDI-TOF
Additionnal Information
KDSR, 3-ketodihydrosphingosine reductase, DHSR, FVT1, ATGP0948-10 µg, ATGP0948-20 µg, ATGP0948-50 µg, ATGP0948-100 µg, ATGP0948-250 µg, ATGP0948-500 µg, ATGP0948-1 mg, ATGP0948-10, ATGP0948-20, ATGP0948-50, ATGP0948-100, ATGP0948-250, ATGP0948-500, ATGP0948-1
References & Citations
Kihara A., et al. (2004) J. Biol. Chem. 279:49243-49250; ; Parkinson, N.J., et al. (2008) Neuromuscul. Disord. 18: 394-397.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl, 0.1mM PMSF
Scientific Category
Metabolism
NCBI Accession Number
NP_002026
Uniprot Accession Number
Q06136
Species
Human
AA Sequence
KPLALPGAH VVVTGGSSGI GKCIAIECYK QGAFITLVAR NEDKLLQAKK EIEMHSINDK QVVLCISVDV SQDYNQVENV IKQAQEKLGP VDMLVNCAGM AVSGKFEDLE VSTFERLMSI NYLGSVYPSR AVITTMKERR VGRIVFVSSQ AGQLGLFGFT AYSASKFAIR GLAEALQMEV KPYNVYITVA YPPDTDTPGF AEENRTKPLE TRLISETTSV CKPEQVAKQI VKDAIQGNFN SSLGSD

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