Recombinant human DNAJC19 protein

• Description :

  DNAJC19 is a single-pass membrane protein that contains a J domain and is localized to the inner membrane of the mitochondrion. Expressed ubiquitously, DNAJC19 functions as a component of the mitochondrial DNAJC19 complex, which is responsible for the ATP-dependent translocation of select proteins from the inner mitochondrial membrane to the mitochondrial matrix. Defects in DNAJC19 are the cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA) . Recombinant human DNAJC19 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

• Product Name Alternative :

  Mitochondrial import inner membrane translocase subunit TIM14, Pam18, TIM14, TIMM14

• Expression System :

  E.coli

• Antigen Species :

  Human

• Tag :

  His-Tag

• Applications :

  SDS-PAGE

• Concentration :

  1 mg/mL (determined by Bradford assay)

• Purity :

  > 90% by SDS-PAGE

• Molecular Weight :

  15.1 kDa (135aa) confirmed by MALDI-TOF

• Additionnal Information :

  TIMM-14, TIMM14, TIMM 14, TIM-14, TIM14, TIM 14, Pam-18, Pam18, Pam 18, Mitochondrial import inner membrane translocase subunit TIM-14, Mitochondrial import inner membrane translocase subunit TIM14, Mitochondrial import inner membrane translocase subunit TIM 14, DNAJC19, ATGP0911-10 µg, ATGP0911-20 µg, ATGP0911-50 µg, ATGP0911-100 µg, ATGP0911-250 µg, ATGP0911-500 µg, ATGP0911-1 mg, ATGP0911-010, ATGP0911-020, ATGP0911-050, ATGP0911-100, ATGP0911-250, ATGP0911-500, ATGP0911-01M

• References & Citations :

  Davey KM., et al. (2006) J Med Genet. 43 (5) :385-93. ; ; Mokranjac D., et al. (2003) EMBO J. 22 (19) :4945-56.

• Storage Conditions :

  Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

• Formulation :

  Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

• Scientific Category :

  Heat Shock Proteins

• NCBI Accession Number :

  NP_660304.1

• Uniprot Accession Number :

  Q96DA6

• Species :

  Human

• AA Sequence :

  GRY VLQAMKHMEP QVKQVFQSLP KSAFSGGYYR GGFEPKMTKR EAALILGVSP TANKGKIRDA HRRIMLLNHP DKGGSPYIAA KINEAKDLLE GQAKK