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Recombinant human DDIT4 protein

CAT: 0112-ATGP0896-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0896-010Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DDIT4, also known as Dig2 or REDD1, is thought to have function in the regulation of reactive oxygen species. In response to stress due to DNA damage and glucocorticoid treatment, DDIT4 is upregulated at the transcriptional level. DDIT4 negatively regulates the mammalian target of Rapamycin, a serine/threonine kinase often referred to as mTOR. It is crucial in the coupling of extra- and intracellular cues to mTOR regulation. Recombinant human DDIT4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
DNA damage-inducible transcript 4 protein, Dig2, FLJ20500, REDD1, RP11-442H21.1, RTP801
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
27.5 kDa (252aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
DDIT4, DNA damage-inducible transcript 4 protein, Dig2, FLJ20500, REDD1, RP11-442H21.1, RTP801, ATGP0896-10 µg, ATGP0896-20 µg, ATGP0896-50 µg, ATGP0896-100 µg, ATGP0896-250 µg, ATGP0896-500 µg, ATGP0896-1 mg, ATGP0896-10, ATGP0896-20, ATGP0896-50, ATGP0896-100, ATGP0896-250, ATGP0896-500, ATGP0896-1
References & Citations
Yoshida T., et al. (2010) Nat Med. 16 (7) :767-73.; ; Regazzetti C., et al. (2010) J Biol Chem. 285 (8) :5157-64.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 1mM EDTA, 30% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_061931
Uniprot Accession Number
Q9NX09
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MPSLWDRFSS SSTSSSPSSL PRTPTPDRPP RSAWGSATRE EGFDRSTSLE SSDCESLDSS NSGFGPEEDT AYLDGVSLPD FELLSDPEDE HLCANLMQLL QESLAQARLG SRRPARLLMP SQLVSQVGKE LLRLAYSEPC GLRGALLDVC VEQGKSCHSV GQLALDPSLV PTFQLTLVLR LDSRLWPKIQ GLFSSANSPF LPGFSQSLTL STGFRVIKKK LYSSEQLLIE EC

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