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Recombinant human NANS protein

CAT: 0112-ATGP0784-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0784-020Size:20 µg
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Description
NANS, also known as SAS, is a 359 amino acid protein that contains one AFP (antifreeze proteins) -like domain and functions in the biosynthesis of sialic acids. Expressed ubiquitously, NANS enzymatically catalyzes the H2O-dependent formation of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), both of which are sialic acids. NANS uses N-acetylmannosamine 6-phosphate as a substrate for Neu5Ac synthesis and mannose 6-phosphate as a substrate for KDN synthesis. Recombinant human NANS protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Sialic acid synthase, SAS, N acetylneuraminate synthase
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
42.4 kDa (379aa) confirmed by MALDI-TOF
Additionnal Information
NANS, Sialic acid synthase, SAS, N acetylneuraminate synthase, ATGP0784-10 µg, ATGP0784-20 µg, ATGP0784-50 µg, ATGP0784-100 µg, ATGP0784-250 µg, ATGP0784-500 µg, ATGP0784-1 mg, ATGP0784-10, ATGP0784-20, ATGP0784-50, ATGP0784-100, ATGP0784-250, ATGP0784-500, ATGP0784-1
References & Citations
Milstein O., et al. (2008) J Biol Chem. 283 (49) :34414-22.; ; Aldape MJ., et al. (2007) J Infect Dis. 195 (12) :1838-45.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 10% glycerol
Scientific Category
Metabolism
NCBI Accession Number
NP_061819
Uniprot Accession Number
Q9NR45
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MPLELELCPG RWVGGQHPCF IIAEIGQNHQ GDLDVAKRMI RMAKECGADC AKFQKSELEF KFNRKALERP YTSKHSWGKT YGEHKRHLEF SHDQYRELQR YAEEVGIFFT ASGMDEMAVE FLHELNVPFF KVGSGDTNNF PYLEKTAKKG RPMVISSGMQ SMDTMKQVYQ IVKPLNPNFC FLQCTSAYPL QPEDVNLRVI SEYQKLFPDI PIGYSGHETG IAISVAAVAL GAKVLERHIT LDKTWKGSDH SASLEPGELA ELVRSVRLVE RALGSPTKQL LPCEMACNEK LGKSVVAKVK IPEGTILTMD MLTVKVGEPK GYPPEDIFNL VGKKVLVTVE EDDTIMEELV DNHGKKIKS

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