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Recombinant human DUTPase/DUT protein

CAT: 0112-ATGP0725-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0725-020Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DuT, also known as duTP pyrophosphatase, is a ubiquitous enzyme that functions in nucleotide metabolism. This protein, in the presence of magnesium ions, is responsible for hydrolyzing duTP to duMP and diphosphate. This reaction is important for keeping the intracellular duTP concentration low so that uracil does not become incorporated into DNA. Extensive incorporation of uracil into DNA can ultimately lead to cell death. This suggests that DuT is essential for cell viability, further implying that it is a potential target for anticancer therapy. Recombinant human DuT protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
FLJ20622, duTPase, duTP pyrophosphatase, duTP diphosphatase, Deoxyuridine Triphosphatase, Deoxyuridine 5-triphosphate nucleotidohydrolase mitochondrial
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
21.6 kDa (204aa) confirmed by MALDI-TOF
Additionnal Information
DuT, Deoxyuridine 5-triphosphate nucleotidohydrolase mitochondrial, duTPase, duTP pyrophosphatase, FLJ20622, Deoxyuridine 5-triphosphate nucleotidohydrolase mitochondrial, Deoxyuridine Triphosphatase, ATGP0725-10 µg, ATGP0725-20 µg, ATGP0725-50 µg, ATGP0725-100 µg, ATGP0725-250 µg, ATGP0725-500 µg, ATGP0725-1 mg, ATGP0725-10, ATGP0725-20, ATGP0725-50, ATGP0725-100, ATGP0725-250, ATGP0725-500, ATGP0725-1
References & Citations
Mclntosh EM., et al. (1992) Proc Natl Acad Sci u S A. 89 (17) :8020-4. ; ; Persson R., et al. (2001) Curr Protein Pept Sci. 2 (4) :287-300.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl.
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_001020419
Uniprot Accession Number
P33316
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MASTVGAAGW KGELPKAGGS PAPGPETPAI SPSKRARPAE VGGMQLRFAR LSEHATAPTR GSARAAGYDL YSAYDYTIPP MEKAVVKTDI QIALPSGCYG RVAPRSGLAA KHFIDVGAGV IDEDYRGNVG VVLFNFGKEK FEVKKGDRIA QLICERIFYP EIEEVQALDD TERGSGGFGS TGKN

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