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Recombinant human RAB27A protein

CAT: 0112-ATGP0556-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0556-100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ras-related protein Rab-27A, also known as RAB27A, belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Also, RAB27A regulates the cytotoxic granule exocytosis and affect T-lymphocyte and macrophage-activation. It is widely expressed with significant expression in pancreatic islets and pituitary tissue, and low expression in brain. Defects in RAB27A cause Griscelli syndrome type 2 (GS2) . Recombinant human RAB27A, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Ras-related protein Rab-27A, GS2, RAM, RAB27, Ras-related protein Rab-27A GTP-binding protein Ram, HsT18676.MGC117246, Rab-27, RAB27A, member RAS oncogene family, Ras-related protein Rab27A.
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
27 kDa (241aa) confirmed by MALDI-TOF
Additionnal Information
Rab27a, Ras-related protein Rab-27A, GS2, RAM, RAB27, Ras-related protein Rab-27A GTP-binding protein Ram, HsT18676.MGC117246, Rab-27, RAB27A, member RAS oncogene family, Ras-related protein Rab27A., ATGP0556-10 µg, ATGP0556-20 µg, ATGP0556-50 µg, ATGP0556-100 µg, ATGP0556-250 µg, ATGP0556-500 µg, ATGP0556-1 mg, ATGP0556-10, ATGP0556-20, ATGP0556-50, ATGP0556-100, ATGP0556-250, ATGP0556-500, ATGP0556-1
References & Citations
Kuroda TS., et al. (2002) J Biol Chem. 277 (11) :9212-8.; ; Barral DC., et al. (2002) J Clin Invest. 110:61-5.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_899059
Uniprot Accession Number
P51159
Species
Human
AA Sequence
MSDGDYDYLI KFLALGDSGV GKTSVLYQYT DGKFNSKFIT TVGIDFREKR VVYRASGPDG ATGRGQRIHL QLWDTAGQER FRSLTTAFFR DAMGFLLLFD LTNEQSFLNV RNWISQLQMH AYCENPDIVL CGNKSDLEDQ RVVKEEEAIA LAEKYGIPYF ETSAANGTNI SQAIEMLLDL IMKRMERCVD KSWIPEGVVR SNGHASTDQL SEEKEKGACG C

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