RegisterLogin

VHLL cDNA

CAT: 0112-ATGD0187-010Size: 10 µgDry Ice: NoHazardous: No
CAT#:0112-ATGD0187-010Size:10 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.
Product Name Alternative
VHLP, VLP
Chromosomal Location
1q22
Antigen Species
Human
Vector Type
PATGen (puc19-derived cloning vector)
Sequence
ATGCCCTGGAGAGCGGGGAACGGGGTGGGTTTAGAGGCCCAGGCGGGCACCCAGGAGGCAGGCCCAGAAGAGTACTGCCAGGAAGAGTTGGGCGCCGAGGAGGAGATGGCAGCCAGAGCAGCATGGCCTGTGCTGCGCTCTGTGAACTCACGCGAGCTCTCCCGGATCATCATCTGCAATCACAGCCCACGAATCGTGCTGCCTGTGTGGCTCAACTACTATGGCAAGCTGCTGCCCTACCTGACGCTGCTGCCCGGCAGGGACTTCCGCATCCACAACTTCCGAAGCCACCCTTGGCTCTTCAGAGATGCAAGGACACATGATAAGCTTCTGGTTAACCAAACTGAATTGTTTGTGCCATCTTCCAATGTTAATGGACAGCCTGTTTTTGCCAACATCACACTGCAGTGTATACCCTGA
Additionnal Information
VHLL, VHLP, VLP, VHLL, ATGD0187-10 µg, ATGD0187-20 µg, ATGD0187-50 µg, ATGD0187-100 µg, ATGD0187-250 µg, ATGD0187-500 µg, ATGD0187-1 mg, ATGD0187-10, ATGD0187-20, ATGD0187-50, ATGD0187-100, ATGD0187-250, ATGD0187-500, ATGD0187-1
Storage Conditions
Store the plasmid at -20C.
Formulation
Lyophilized
Scientific Category
Ubiquitination
NCBI Accession Number
NP_001004319.1
Species
Human
Preparation
1. Centrifuge at 7000rpm for 1 minute.; ;2. Carefully open the vial and add 100 µL of sterile water to dissolve the DNA.; ; Each tube contains approximately 10 µg of lyophilized plasmid.
RNA Reference
NM_001004319.1
DNA Size
420bp
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.

Related Products

CatalogName
ATGD0009-010GLRX3 cDNA
ATGD0012-010ARG1 cDNA
ATGD0016-010MAP2K2 cDNA
ATGD0018-010RAN cDNA
ATGD0019-010ISG20 cDNA
ATGD0024-010AKR1D1 cDNA
ATGD0025-010FABP12 cDNA
ATGD0028-010ANP32A cDNA
ATGD0031-010LGALSL cDNA
ATGD0033-010PITPNB cDNA

Alternative Products

CatalogName
552358VHLL cDNA
MBS1266427-01VHLL cDNA Clone
MBS200702-01VHLL
MBS8527176-01VHLL Antibody
581170-01VHLL (FITC)
T36275XStAx-VHLL
581171-01VHLL (HRP)
HY-148880-01VHLL-BCN
TS419675P5VHLL CytoSection
581169-01VHLL (Biotin)

Popular Products