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Human Caveolin-1 antibody

CAT: 0112-ATGA0540-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0540-050Size:50 µL
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Description
The identification of caveolin-1 (CAV1) as the main structural component of caveolae, together with the finding that CAV1 might serve as a molecular organizer for membrane multiprotein complexes involved in cellular traffic, endo-and transcytosis, cell adhesion and signal transduction prompted a new impulse in the research on these intracellular organells. One of the properties of CAV1 was its insolubility in cold non-ionic detergents together with apical markers in epithelial cell. Also, cholesterol is essential for caveolae formation and maintenance, and caveolae structure is highly sensitive to cholesterol depletion or treatment with cholesterol binding drugs. CAV1 tightly and specifically binds free cholesterol and artificial cholesterol containing vesicles.
Product Name Alternative
VIP 21, CAV, CAV 1, CAV1, caveolae protein 22 kD, caveolin 1 alpha isoform, caveolin 1 beta isoform, Caveolin 1 caveolae protein 22kDa, Caveolin1, cell growth-inhibiting protein 32, MSTP085, OTTHUMP00000025031, VIP 21, VIP21
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human CAV1 (1-104aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
AT4C1
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
Caveolin1, ATGA0540-10 µg, ATGA0540-20 µg, ATGA0540-50 µg, ATGA0540-100 µg, ATGA0540-250 µg, ATGA0540-500 µg, ATGA0540-1 mg, ATGA0540-10, ATGA0540-20, ATGA0540-50, ATGA0540-100, ATGA0540-250, ATGA0540-500, ATGA0540-1
References & Citations
Van Meer, G., et al. (2008) Nat Rev Mol Cell Biol. 9: 112-124; ; Todeschini, R.A. et al. (2008) Biochim Biophy Acta 1780: 421-433; ; Lajoie, P et al. (2007) J Cell Mol Med 11: 644-653
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Cancer
NCBI Accession Number
NP_001744
Uniprot Accession Number
Q03135
WB Description
The tissue lysate (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CAV1 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: Mouse heart tissue lysate
IF Description
ICC/IF analysis of CAV1 in A549 cells. The cell was stained with ATGA0540 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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