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Human ActiCTA1 antibody

CAT: 0112-ATGA0517-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0517-100Size:100 µL
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Description
ACTA1 belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Product Name Alternative
ACTA, ACTA1, Actin, alpha 1, Alpha actin 1, Alpha skeletal muscle, Alpha skeletal muscle actin, ASMA, CFTD, CFTDM, MPFD, NEM1, NEM2, NEM3, Skeletal muscle
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human Actin (13-377aa) purified from E.coli
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
AT2F5
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
Skeletal muscle, NEM3, NEM2, NEM1, MPFD, CFTDM, CFTD, ASMA, Alpha-actin-1, alpha1, Alpha skeletal muscle actin, Alpha skeletal muscle, Alpha actin 1, alpha 1, Actin, ACTA1, ACTA, ACTA 1, Alpha actin1, NEM 3, NEM 2, NEM 1, Actin, ATGA0517-10 µg, ATGA0517-20 µg, ATGA0517-50 µg, ATGA0517-100 µg, ATGA0517-250 µg, ATGA0517-500 µg, ATGA0517-1 mg, ATGA0517-010, ATGA0517-020, ATGA0517-050, ATGA0517-100, ATGA0517-250, ATGA0517-500, ATGA0517-01M
References & Citations
Moreno CAM , et al., (2017) Pediatr. Neurol. 75: 11-16. ; ; Loumaye A , et al., (2017) J Cachexia Sarcopenia Muscle 8 (5) : 768-777.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot analysis and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Cancer
NCBI Accession Number
NP_001091
Uniprot Accession Number
P68133
WB Description
The tissue and cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Actin antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: Mouse Lung Tissue lysate; ; Lane 2.: HeLa cell lysate; ; Lane 3.: A549 cell lysate; ; Lane 4.: A431 cell lysate; ; Lane 5.: Raji cell lysate;
IF Description
ICC/IF analysis of Actin in HeLa cells. The cell was stained with ATGA0517 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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