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Human ING2 antibody

CAT: 0112-ATGA0290-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0290-100Size:100 µL
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Description
ING2 is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. This protein seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Also, It is component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides.
Product Name Alternative
Inhibitor of growth protein 2, ING1L, P33ing2
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human ING2 (1-280aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1b κ
Clone
AT39E5
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
ING2, ATGA0290-10 µg, ATGA0290-20 µg, ATGA0290-50 µg, ATGA0290-100 µg, ATGA0290-250 µg, ATGA0290-500 µg, ATGA0290-1 mg, ATGA0290-10, ATGA0290-20, ATGA0290-50, ATGA0290-100, ATGA0290-250, ATGA0290-500, ATGA0290-1
References & Citations
Entrez Gene: ING2 inhibitor of growth family, member 2.; ; Shimada Y., et al. (1999) Cytogenet Cell Genet 83 (3-4) : 232-5.; ; Nagashima M., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98: 9671-9676.; ; Gozani O., et al. (2003) Cell 114: 99-111.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_001555
Uniprot Accession Number
Q9H160
WB Description
The cell lysate of HeLa (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human ING2 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
IF Description
ICC/IF analysis of ING2 in Hep3B cells. The cell was stained with ATGA0290 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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