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Human SNTA1 antibody

CAT: 0112-ATGA0254-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0254-050Size:50 µL
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Description
SNTA1 (Syntrophin alpha 1) is 505 amino acid protein. SNTA1 is adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. It may link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. SNTA1 plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Defects of SNTA1 are the cause of long QT syndrome type 12 (LQT12) .
Product Name Alternative
Syntrophin alpha 1, Syntrophin, alpha 1, dJ1187J4.5, LQT12, SNT1, TACIP1
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human SNTA1 (1-505aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
AT1E1
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
SNTA1, ATGA0254-10 µg, ATGA0254-20 µg, ATGA0254-50 µg, ATGA0254-100 µg, ATGA0254-250 µg, ATGA0254-500 µg, ATGA0254-1 mg, ATGA0254-10, ATGA0254-20, ATGA0254-50, ATGA0254-100, ATGA0254-250, ATGA0254-500, ATGA0254-1
References & Citations
Wu, G., et al. (2008) Circ Arrhythm Electrophysiol 1: 193-201.; ; Ahn, A.H., et al. (1996) J Biol Chem 271 (5) : 2724-30.; ; Yang, B., et al (1995) J Biol Chem 270 (10) : 4975-8.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_003089
Uniprot Accession Number
Q13424
WB Description
The cell lysate of HepG2 (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human SNTA1 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
IF Description
ICC/IF analysis of SNTA1 in HeLa cells. The cell was stained with ATGA0254 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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