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Human KRT23 antibody

CAT: 0112-ATGA0225-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0225-100Size:100 µL
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Description
KRT23, also known as cytokeratin 23, is a 422 amino acid intermediate filament protein. The human KRT23 gene is located on chromosome 17q21. 2. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, and maintenance of epithelial cells structure. Cytokeratins are described to be differentiation markers in several epithelial cancers.
Product Name Alternative
CK-23, CK23, Cytokeratin-23, DKFZP434G032, HAIK1, Cytokeratin 23, MGC26158, K23, K1C23, HAIK 1, Histone deacetylase inducible keratin 23, type I cytoskeletal 23
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human KRT23 (271-422aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT2F6
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF, FACS
Purification Method
By protein-G affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
KRT23, ATGA0225-10 µg, ATGA0225-20 µg, ATGA0225-50 µg, ATGA0225-100 µg, ATGA0225-250 µg, ATGA0225-500 µg, ATGA0225-1 mg, ATGA0225-10, ATGA0225-20, ATGA0225-50, ATGA0225-100, ATGA0225-250, ATGA0225-500, ATGA0225-1
References & Citations
Birkenkamp-Demtroder K., et al. (2007) Mol Oncol 1 (2) : 181-195.; ; Zhang J.S., et al. (2001) Genes Chromosomes Cancer 30: 123-135.; ; Schweizer J., et al. (2006) Cell Biol 174: 169-174.; ; Rogers M.A., et al. (2004) Differentiation 72: 527-540.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot, ICC/IF and FACS analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_056330
Uniprot Accession Number
Q9C075
WB Description
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human KRT23 antibody (1:3000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: HeLa cell lysate; ; Lane 2.: HepG2 cell lysate
FACS Description
Flow cytometry analysis of KRT23 in Hep3B cell line, staining at 2-5ug for 1x10^6cells. The secondary antibody used goat anti-mouse IgG Alexa fluor 488 conjugate.
IF Description
ICC/IF analysis of KRT23 in Hep3B cells. The cell was stained with ATGA0225 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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