Rosiptor

CAT: 0804-HY-109011-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-109011-01Size:5 mg
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Description
Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro[1][2].
CAS Number
[782487-28-9]
Product Name Alternative
AQX-1125
UNSPSC
12352211
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Rosiptor.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : 150 mg/mL (ultrasonic; warming)
Smiles
C[C@@]([C@H]1CO)(CC[C@H](O)C1)[C@](CC[C@@]2(C)[C@@]3([H])CCC2=C)([H])[C@H]3CN
Molecular Formula
C20H35NO2
Molecular Weight
321.50
References & Citations
[1]Stenton GR, et al. Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo. Br J Pharmacol. 2013 Mar;168 (6) :1506-18.|[2]Cross J, et al. AQX-1125, small molecule SHIP1 activator inhibits NSC-125066-induced pulmonary fibrosis. Br J Pharmacol. 2017 Sep;174 (18) :3045-3057.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
MBS5764290Rosiptor
A19434-1Rosiptor 1mg
A19434-10Rosiptor 10mg
A19434-100Rosiptor 100mg
MF-0038116-01Rosiptor acetate
A19434-5Rosiptor 5mg
A19434-25Rosiptor 25mg
A19434-50Rosiptor 50mg
A19434-10mM-DRosiptor 10mM * 1mL in DMSO

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