Lys-CoA (TFA)

• Description:

  Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50=50-500 nM) . Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC50=200 μM) . Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation[1][2].

• Product Name Alternative:

  Lys-coenzyme A

• UNSPSC:

  12352005

• Target:

  Histone Acetyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lys-coa-tfa.html

• Purity:

  99.42

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32.O=C(O)C(F)(F)F

• Molecular Formula:

  C33H54F3N10O21P3S

• Molecular Weight:

  1108.82

• References & Citations:

  [1]Cebrat M, et al. Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg Med Chem. 2003;11 (15) :3307-3313.|[2]Lau OD, et al. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol Cell. 2000;5 (3) :589-595.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CBP/p300