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3-Methylazepane Hydrochloride

CAT: 1139-1798010-22-6-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:1139-1798010-22-6-01Size:10 g
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Description
3-Methylazepane Hydrochloride (CAS: 1798010-22-6) is a saturated monosubstituted seven-membered nitrogen heterocyclic hydrochloride salt. It is formed by acidification of 3-methylazepane free base with hydrochloric acid, featuring stable crystal state and excellent water solubility compared with oily free amine. This compound has a single methyl substituent at the 3-position of hexahydroazepane ring, and the cyclic secondary amine is protonated into ammonium salt. It avoids volatile and oxidative defects of free azepane, retains complete ring skeleton reactivity, and is a commonly used raw material for downstream Boc protection, amide coupling and chiral drug synthesis.
Synonyms
3-Methylazepane hydrochloride, 3-Methylhexahydroazepine hydrochloride, 3-Methylazepanium chloride, Hexahydro-3-methyl-1H-azepine hydrochloride
HS Code
2933999090
Applications
1. Azepane Parent Intermediate Synthesis: 3-Methylazepane Hydrochloride (CAS: 1798010-22-6) serves as the core raw material for preparing various Boc-protected, fluorinated and carboxylated azepane derivatives. It can be directly neutralized to obtain free 3-methylazepane, matching diversified subsequent ring modification reactions. 2. Pharmaceutical Heterocyclic Building Block: The 3-methyl substituted azepane skeleton has good lipophilicity and biological target binding ability. This hydrochloride intermediate is widely used in the development of central nervous system drugs, analgesics and GPCR target small molecule drugs. 3. Amine Protection and Multi-step Organic Synthesis: As a stable cyclic amine salt, 3-Methylazepane Hydrochloride (CAS: 1798010-22-6) is suitable for one-pot Boc protection reaction. It features mild reaction conditions, high conversion rate and low side impurities, perfectly adapted to conventional laboratory and pilot-scale synthetic routes. 4. Medicinal Chemistry SAR Research: Used as a standard reference compound for studying substituent effect of azepane rings. Researchers compare the activity difference between 3-methylazepane and unsubstituted azepane to optimize molecular structure and improve druggability of lead compounds.
Purity
≥ 98% (HPLC)
Molecular Formula
C7H16ClN
Molecular Weight
149.66
Shelf Life
2 years under proper storage
Appearance
White crystalline powder
Grade
Pharmaceutical intermediate grade, Laboratory research grade
Density
0.92±0.05 g/cm3 at 25°C
Melting Point
186-190 °C
EINECS
Not available

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