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4,4-difluoroazepane

CAT: 1139-1094073-72-9-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:1139-1094073-72-9-01Size:10 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4,4-difluoroazepane with CAS 1094073-72-9 is a geminal difluorinated seven-membered nitrogen heterocyclic intermediate. This fluorinated azepane derivative features two fluorine atoms attached to the 4-position carbon of the azepane ring, forming a stable non-hydrolyzable carbonyl mimic structure. The gem-difluoro substitution greatly improves molecular metabolic stability and lipophilicity compared with conventional azepane intermediates. This product is commonly prepared and stored as hydrochloride salt for better stability, and it is sensitive to humid air and high temperature, requiring low-temperature sealed storage to avoid deliquescence and decomposition.
Synonyms
4,4-Difluorohexahydroazepine, 4,4-Difluoro-1H-azepane, MFCD17017751, 4,4-Difluoroazepane free base
HS Code
2933399090
Applications
1. Fluorinated Pharmaceutical Intermediate Synthesis: 4,4-difluoroazepane (CAS 1094073-72-9) serves as a key fluorinated heterocyclic building block for novel small molecule drugs, especially central nervous system regulators and anti-inflammatory agents. The difluorinated structure effectively blocks in-vivo metabolic degradation and prolongs drug half-life. 2. Medicinal Chemistry Fragment Library Construction: This compound is a high-value fluorinated fragment for high-throughput drug screening. 4,4-difluoroazepane (CAS 1094073-72-9) helps pharmaceutical R&D teams screen lead compounds with optimized pharmacokinetic properties and higher target binding activity. 3. Custom Organic Synthesis & Derivatization: It has active secondary amine groups on the azepane ring, supporting amidation, alkylation and acylation reactions for custom synthesis of downstream fluorinated azepane derivatives, meeting personalized synthesis demands for fine chemical laboratories and pharmaceutical factories. 4. Bioisostere Replacement Research: Used as carbonyl bioisostere in drug molecular design, replacing unstable ketone and aldehyde groups in original drug molecules to enhance overall molecular stability without reducing biological activity.
Purity
≥97%
Molecular Formula
C6H11F2N
Molecular Weight
135.16
Shelf Life
2 years under proper storage
Appearance
White to off-white crystalline solid
Grade
Pharmaceutical Intermediate Grade, Research Grade
Density
1.10 g/cm3 (calculated)
Melting Point
192-196 °C (hydrochloride solid form)
EINECS
Not available

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