L-prolinol

L-prolinol with CAS 23356-96-9 is a high-purity chiral amino alcohol derived from L-proline, belonging to premium chiral fine chemical intermediates. Its molecular structure contains pyrrolidine secondary amine and primary hydroxyl group with fixed single (S) chiral configuration, featuring stable stereochemical structure, excellent solubility in polar organic solvents and moderate dual-functional reactivity. This chiral compound hardly undergoes racemization under sealed low-temperature storage, and can participate in condensation, cyclization and coordination reactions without extra protection steps. It is a core chiral building block widely applied in asymmetric catalytic synthesis, chiral ligand preparation and chiral pharmaceutical intermediate development.

L- (+) -Prolinol, (S) - (+) -2-Pyrrolidinemethanol, (S) - (+) -2- (Hydroxymethyl) pyrrolidine, H-L-Pro-OL, S-2-Hydroxymethyl-pyrrolidine

Not available

1. Asymmetric Organic Synthesis Chiral Catalyst Precursor: L-prolinol (CAS 23356-96-9) is a classic small-molecule organocatalyst raw material for asymmetric synthesis. It can directly catalyze aldol, Michael and Mannich reactions with high stereoselectivity, and is also derivatized into various prolinol-based chiral catalysts to realize high-efficiency asymmetric construction of chiral carbon centers, widely used in advanced synthetic chemistry research. 2. Chiral Ligand & Metal Catalyst Modifier: This CAS 23356-96-9 chiral amino alcohol can coordinate with transition metals to prepare high-selectivity chiral metal ligands. The dual amine-hydroxyl coordination sites effectively adjust the steric and electronic environment of catalytic center, significantly improving enantioselectivity of hydrogenation, coupling and cyclization catalytic reactions. 3. Chiral Pharmaceutical Intermediate Synthesis: L-prolinol serves as key starting material for synthesizing pyrrolidine-based chiral drugs. Its stable (S) chiral skeleton can be embedded into drug molecular frameworks via multi-step derivatization, optimizing target binding affinity and metabolic stability of small-molecule chiral therapeutics, frequently used in R&D of central nervous system drugs and anti-viral chiral intermediates. 4. Laboratory Stereochemistry Research Reagent: With high chiral purity ≥98% and stable stereostructure, CAS 23356-96-9 compound acts as standard laboratory reagent for asymmetric catalytic mechanism research, chiral separation auxiliary agent preparation and customized synthesis of novel chiral fine chemicals in pharmaceutical and chemical research institutes.

≥98%

C5H11NO

101.15

2 years under proper storage

Colorless transparent oily liquid or white crystalline solid

Pharmaceutical intermediate grade

1.036 g/mL at 20 °C

42-44 °C

74-76 °C at 2 mmHg