2-Chloro-3-fluorophenylboronic acid

2-Chloro-3-fluorophenylboronic acid (CAS: 871329-52-1) is a high-purity di-halogen substituted aromatic boronic acid fine chemical intermediate. Its molecular structure features ortho-chloro and meta-fluoro dual halogen substitution on the benzene ring, equipped with active boronic acid functional groups. The unique chlorine-fluorine co-substituted structure endows 2-Chloro-3-fluorophenylboronic acid (CAS: 871329-52-1) with excellent chemical stability, strong molecular modification activity and high reaction selectivity. This product exhibits low hydrolysis rate and stable structural performance in complex industrial reaction environments, with fewer by-products and consistent batch quality. It serves as a critical synthetic building block for halogenated drug intermediate synthesis, fluorochlorinated aromatic derivative preparation and large-scale industrial Suzuki cross-coupling reactions.

2-Chloro-3-fluorobenzeneboronic acid, 3-Fluoro-2-chlorophenylboronic acid, 2-Chloro-3-fluoro-benzeneboronic acid

1. Pharmaceutical Intermediate Synthesis Application: 2-Chloro-3-fluorophenylboronic acid (CAS: 871329-52-1) is a core raw material for the synthesis of high-value halogenated pharmaceutical intermediates. The chlorine and fluorine dual substitution structure can effectively optimize the lipophilicity, metabolic stability and pharmacological activity of drug molecules, and is widely used in the industrial R&D and production of anti-inflammatory, antibacterial and anti-tumor drugs. 2. Industrial Suzuki Cross-Coupling Reaction Application: 2-Chloro-3-fluorophenylboronic acid (CAS: 871329-52-1) is commonly applied in large-scale industrial cross-coupling synthesis of difunctional halogenated biphenyl compounds. Its stable di-halogenated aromatic structure maintains high coupling activity in continuous production, significantly improving the synthesis yield and structural purity of downstream fine chemical products. 3. Halogenated Fine Chemical Derivatization Application: 2-Chloro-3-fluorophenylboronic acid (CAS: 871329-52-1) supports customized derivation of high-performance fluorochlorinated fine chemicals. The active boronic acid group enables precise molecular grafting and structural modification, providing high-purity intermediates for the preparation of chemical additives and organic functional materials. 4. Laboratory Organic Synthesis Research Application: 2-Chloro-3-fluorophenylboronic acid (CAS: 871329-52-1) acts as a standard experimental reagent for researching the reaction mechanism of di-halogen substituted phenylboronic acid, supporting laboratory new compound development and process optimization of halogenated aromatic intermediates.

98%

C6H5BClFO2

174.37

2 years under proper storage

White to Off-white Crystalline Powder

Synthetic Grade / Research Grade / Pharmaceutical Intermediate Grade

1.43±0.1 g/cm3