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Ethyl cinnamate

CAT: 0804-HY-Y0121-01Size: 100 gDry Ice: NoHazardous: No
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CAT#:0804-HY-Y0121-01Size:100 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC50 values of 0.30 mM and 0.38 mM in rat aorta[1][2][3][4].
CAS Number
103-36-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Parasite; VEGFR
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ethyl-cinnamate.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC)/C=C/C1=CC=CC=C1
Molecular Formula
C11H12O2
Molecular Weight
176.22
Precautions
H302, H315, H319, H335
References & Citations
[1]S P Bhatia, et al. Fragrance material review on ethyl cinnamate. Food Chem Toxicol. 2007;45 Suppl 1:S90-4.|[2]Anika Klingberg, et al. Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy. J Am Soc Nephrol. 2017 Feb;28 (2) :452-459.|[3]Wang S, et al. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. J Ethnopharmacol. 2024 May 23;326:117913. |[4]Othman R, et al. Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta. Planta Med. 2002 Jul;68 (7) :655-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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