N-BOC-piperazine

N-BOC-piperazine (CAS: 57260-71-6) is a high-purity monoprotected piperazine fine chemical. Its molecular structure features a single tert-butoxycarbonyl (Boc) group selectively bonded to one nitrogen atom of the piperazine ring, retaining a free active amino group for secondary modification. This compound exhibits stable chemical properties, moderate reactivity and excellent solubility in common organic solvents. It is air-sensitive and requires low-temperature sealed storage to avoid oxidative deterioration and moisture absorption. N-BOC-piperazine (57260-71-6) serves as a core intermediate for selective derivatization of piperazine compounds, widely utilized in pharmaceutical intermediate synthesis, organic catalytic reaction research and fine chemical customization.

1-Boc-piperazine, tert-Butyl 1-piperazinecarboxylate, 1- (tert-Butoxycarbonyl) piperazine, Piperazine-1-carboxylic acid tert-butyl ester

29335995

1. Pharmaceutical Intermediate Synthesis N-BOC-piperazine (CAS: 57260-71-6) is a critical building block for the synthesis of piperazine-containing drug molecules. The single Boc protection structure effectively avoids excessive substitution side reactions, enabling precise synthesis of bioactive pharmaceutical intermediates for anti-tumor, anti-inflammatory and neurological drug development and industrial production. 2. Selective Organic Derivatization Reactions N-BOC-piperazine (57260-71-6) is widely applied in selective amine modification and organic synthesis. The reserved free secondary amine group can undergo alkylation, acylation and coupling reactions, supporting directional synthesis of asymmetric disubstituted piperazine derivatives for high-end fine chemical customization. 3. Buchwald-Hartwig Coupling Reaction Raw Material N-BOC-piperazine (CAS: 57260-71-6) acts as a standard nitrogen coupling substrate for Buchwald-Hartwig amination reactions. It can efficiently react with aryl halide compounds under mild catalytic conditions to construct aryl piperazine structural units, which is commonly used in the preparation of complex heterocyclic functional compounds. 4. Laboratory Synthetic Process Research N-BOC-piperazine (57260-71-6) is a conventional high-purity laboratory reagent. It is used for the exploration of selective protection and deprotection processes of piperazine groups, optimization of heterocyclic compound synthetic routes and mechanism research of nitrogen-containing organic reactions in academic and industrial laboratories.

≥98%

Store at 2-8 °C in dry, sealed, inert atmosphere and dark ventilated environment, avoid air exposure and moisture absorption to prevent deterioration

2 years under proper storage

White to light yellow low melting crystalline solid / waxy solid

Research Grade, Pharmaceutical Intermediate Grade, Fine Chemical Grade

1.030±0.06 g/cm3

43-47 °C

98-100 °C at 10 mmHg