EGFR-IN-78

EGFR-IN-78

• CAS Number: 3042104-73-1
• UNSPSC Description: EGFR-IN-78 (compound A5)，a 2-aminopyrimidine derivative，is a reversible inhibitor of EGFRC797S-TK，and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity，inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase[1].
• Target Antigen: Apoptosis; EGFR
• Type: Reference compound
• Related Pathways: Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/egfr-in-78.html
• Solubility: 10 mM in DMSO
• Smiles: BrC1=C(N[C@@H]2CCCN(S(C3CC3)(=O)=O)C2)N=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C1
• Molecular Weight: 550.51
• References & Citations: [1]Mao YZ, et al. Design, synthesis and evaluation of new pyrimidine derivatives as EGFRC797S tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2023 Jul 15;91:129381.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported