PAC-1

• Description:

  PAC-1 is a procaspase-3 activator that induces apoptosis in cancer cells with an EC50 of 2.08 μM.

• Product Name Alternative:

  Procaspase activating compound 1

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335, H400

• Target:

  Apoptosis; Autophagy; Caspase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/PAC-1.html

• Purity:

  99.88

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles:

  O=C(N/N=C/C1=CC=CC(CC=C)=C1O)CN2CCN(CC3=CC=CC=C3)CC2

• Molecular Formula:

  C23H28N4O2

• Molecular Weight:

  392.49

• Precautions:

  H302, H315, H319, H335, H400

• References & Citations:

  [1]Wang F, et al. A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts. Mol Oncol. 2014 Dec;8 (8) :1640-52.|[2]Seervi M, et al. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1) . Cell Death Dis. 2013 Dec 19;4:e968.|[3]Putt KS, et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2 (10) :543-50.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  Caspase 3

• CAS Number:

  [315183-21-2]