PAC-1

• UNSPSC Description:

  PAC-1 is a procaspase-3 activator that induces apoptosis in cancer cells with an EC50 of 2.08 μM.

• Target Antigen:

  Apoptosis; Autophagy; Caspase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/PAC-1.html

• Smiles:

  O=C(N/N=C/C1=CC=CC(CC=C)=C1O)CN2CCN(CC3=CC=CC=C3)CC2

• Molecular Weight:

  392.49

• References & Citations:

  [1]Wang F, et al. A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts. Mol Oncol. 2014 Dec;8(8):1640-52.|[2]Seervi M, et al. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell Death Dis. 2013 Dec 19;4:e968.|[3]Putt KS, et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2(10):543-50.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  315183-21-2