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STAT5b Polyclonal Antibody

CAT: 1027-RA35084-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:1027-RA35084-01Size:50 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Signal transducer and activator of transcription 5B (STAT5B) Homo sapiens The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL) . The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provi
Product Name Alternative
Signal transducer and activator of transcription 5B; YM3465
Gene ID
6777
Swiss Prot
P51692
Cross Reactivity
Human; Rat; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC-p; IF (paraffin section)
Dilution
WB: 1:500-1:2000 IHC: 1:50-1:200
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
90
Storage Conditions
-20°C/1 year
Protein Weight
90

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