PKD1 Polyclonal Antibody

Polycystin 1, transient receptor potential channel interacting (PKD1) Homo sapiens This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1) . ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on c

5310

P98161

Human; Rat; Mouse

Rabbit

IHC-p; IF (paraffin section)

IHC-p 1:50-300

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

473

-20°C/1 year