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MRP5 Polyclonal Antibody

CAT: 1027-RA33380-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1027-RA33380-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ATP binding cassette subfamily C member 5 (ABCC5) Homo sapiens The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9- (2-phosphonylmethoxyethyl) adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside
Gene ID
10057
Swiss Prot
O15440
Cross Reactivity
Human; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Molecular Weight
158
Storage Conditions
-20°C/1 year
Protein Weight
158

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