HLA-DOβ Polyclonal Antibody

• Background:

  Major histocompatibility complex, class II, DO beta (HLA-DOB) Homo sapiens HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

• Product Name Alternative:

  HLA-DOB; HLA class II histocompatibility antigen; DO beta chain; MHC class II antigen DOB

• Gene ID:

  3112

• Swiss Prot:

  P13765

• Cross Reactivity:

  Human

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Dilution:

  Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Molecular Weight:

  30

• Storage Conditions:

  -20°C/1 year

• Protein Weight:

  30