Pyruvate Dehydrogenase E2 mouse mAb

CAT: 1027-RA11913-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:1027-RA11913-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Dihydrolipoamide S-acetyltransferase (DLAT) Homo sapiens This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC) . PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC) . In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lact
Product Name Alternative
70 kDa mitochondrial autoantigen of primary biliary cirrhosis; anti DLAT; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide; Dihydrolipoamide S Acetyltransferase; Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) ; Dihydrolipoamide S-Acetyltransferase; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial; DLAT; DLAT; DLTA; E2; E2 component of pyruvate dehydrogenase complex; EC 2.3.1.12; M2 antigen complex 70 kDa subunit; M2 Antigen Complex 70kD Subunit; mitochondrial; ODP2_HUMAN; PBC; PDC E2; PDC-E2; PDCE2; Pyruvate dehydrogenase complex component E2; Pyruvate dehydrogenase complex E2 subunit; S acetyltransferase component of pyruvate dehydrogenase complex.
Gene ID
1737
Swiss Prot
P10515
Cross Reactivity
Human; Mouse
Clonality
Monoclonal
Source
Mouse
Applications
WB; ICC; IP
Dilution
Wb 1:1000 icc 1:300
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
69
Storage Conditions
-20°C/1 year
Protein Weight
69

Related Products

CatalogName
RA11912-01Pyruvate dehydrogenase (lipoamide) α 1 mouse mAb
RE1612M-01Mouse PDP (Pyruvate Dehydrogenase Phosphatase) ELISA Kit
RA10747-01Aldehyde dehydrogenase 10 mouse mAb
RE1611M-01Mouse PDK4 (Pyruvate Dehydrogenase Kinase Isozyme 4) ELISA Kit
RE1612R-01Rat PDP (Pyruvate Dehydrogenase Phosphatase) ELISA Kit
RE1612H-01Human PDP (Pyruvate Dehydrogenase Phosphatase) ELISA Kit
RE3014M-01Mouse PDHA1 (Pyruvate dehydrogenase E1 component subunit alpha) ELISA Kit
RE3454R-01Rat PDK4 (Pyruvate Dehydrogenase Kinase Isozyme 4) ELISA Kit
RE1611H-01Human PDK4 (Pyruvate Dehydrogenase Kinase Isozyme 4) ELISA Kit
RE3010H-01Human PDHB (Pyruvate dehydrogenase E1 component subunit Beta) ELISA Kit

Alternative Products

CatalogName
E2200270Pyruvate Dehydrogenase/Pyruvate Dehydrogenase E1 alpha Mouse mAb
QY-E21790Mouse Pyruvate Dehydrogenase (PDH)
27025Pyruvate Dehydrogenase Mouse mAb
E2T200678Pyruvate Dehydrogenase E2 Mouse mAb
GTR10386635Mouse Pyruvate Dehydrogenase Beta ELISA kit
GTR10374216Mouse Pyruvate Dehydrogenase E1 ELISA kit
GTR10410042Mouse Pyruvate Dehydrogenase Phosphatase ELISA kit
GTR10396608Mouse Pyruvate Dehydrogenase Alpha ELISA kit
AMM00969-01Pyruvate Dehydrogenase E2 Mouse Monoclonal Antibody
CK-bio-16854-01Mouse Pyruvate dehydrogenase alpha 1 (PDHA1)

Popular Products