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Acetohexamide (Standard)

CAT: 0804-HY-B0881R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0881R-01Size:5 mg
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Description
Acetohexamide (Standard) is the analytical standard of Acetohexamide. This product is intended for research and analytical applications. Acetohexamide is an orally active first-generation sulfonylurea agent used in research related to type 2 diabetes and cancer. Acetohexamide exerts reductase activity in human erythrocytes. Acetohexamide stimulates the pancreas to secrete insulin. Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. Acetohexamide can inhibit the formation of circular chemorepellent induced defects (CCIDs) in lymphendothelial cell (LEC) monolayers. Acetohexamide inhibits markers of epithelial-to-mesenchymal-transition and migration. Acetohexamide suppresses the synthesis of 12 (S) -HETE. Acetohexamide can potentiate hypoglycaemic action[1][2][3][4].
CAS Number
968-81-0
UNSPSC
12352005
Target
Potassium Channel; Reference Standards
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/acetohexamide-standard.html
Smiles
O=S(C1=CC=C(C(C)=O)C=C1)(NC(NC2CCCCC2)=O)=O
Molecular Formula
C15H20N2O4S
Molecular Weight
324.40
References & Citations
[1]Kretschy N, et al. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer. 2013 Feb 19;108 (3) :570-8.|[2]Kishimoto, M., et al., (1994) . Carbonyl reductase activity for acetohexamide in human erythrocytes. Drug metabolism and disposition: the biological fate of chemicals, 22 (3), 367–370.|[3]Kretschy, N., et al., (2013) . In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. British journal of cancer, 108 (3), 570–578.|[4]Imamura, Y., et al., (1990) . Mechanism of pharmacodynamic and pharmacokinetic interactions between acetohexamide and phenylbutazone in rabbits. Pharmacology & toxicology, 67 (5), 415–419.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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