Acetohexamide

• Description:

  Acetohexamide is an orally active first-generation sulfonylurea agent used in research related to type 2 diabetes and cancer. Acetohexamide exerts reductase activity in human erythrocytes. Acetohexamide stimulates the pancreas to secrete insulin. Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. Acetohexamide can inhibit the formation of circular chemorepellent induced defects (CCIDs) in lymphendothelial cell (LEC) monolayers. Acetohexamide inhibits markers of epithelial-to-mesenchymal-transition and migration. Acetohexamide suppresses the synthesis of 12 (S) -HETE. Acetohexamide can potentiate hypoglycaemic action[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H312, H332

• Target:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Metabolic Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Acetohexamide.html

• Purity:

  99.67

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=CC=C(C(C)=O)C=C1)(NC(NC2CCCCC2)=O)=O

• Molecular Formula:

  C15H20N2O4S

• Molecular Weight:

  324.40

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]White JA, et al. Nonhypoglycemic drug reactions of agents used to treat diabetes. Endocrinol Metab Clin North Am. 2000 Dec;29 (4) :803-11.|[2]Kishimoto, M., et al., (1994) . Carbonyl reductase activity for acetohexamide in human erythrocytes. Drug metabolism and disposition: the biological fate of chemicals, 22 (3), 367–370.|[3]Kretschy, N., et al., (2013) . In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. British journal of cancer, 108 (3), 570–578.|[4]Imamura, Y., et al., (1990) . Mechanism of pharmacodynamic and pharmacokinetic interactions between acetohexamide and phenylbutazone in rabbits. Pharmacology & toxicology, 67 (5), 415–419.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [968-81-0]