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NDT-19795

CAT: 0804-HY-158024-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-158024-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NDT-19795 is an effective inhibitor of the NLRP3 inflammasome with an IC50 value of 66 nM in the PBMC method and 4.7 μM in the WB method. NDT-19795 is a carboxylic acid-active substance that can be converted from NT-0796 within cells. NDT-19795 can be used for the study of neurological diseases[1].
CAS Number
2272917-12-9
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ndt-19795.html
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC([C@@H](CC1=NC=CC=N1)OC(NC2=C3C(CCC3)=CC4=C2CCC4)=O)=O
Molecular Formula
C20H21N3O4
Molecular Weight
367.40
References & Citations
[1]Harrison D, et al. Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders. J Med Chem. 2023;66 (21) :14897-14911.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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