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C4a/b Antibody

CAT: 1071-OM636707-01Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1071-OM636707-01Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human C4A/C4B. AA range:721-770
Antibody Type
Primary Antibodies
Product Name Synonym
C4A antibody; CO4 antibody; CPAMD2 antibody; Complement C4-A antibody; Acidic complement C4 antibody; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2 antibody; C4B antibody; CO4 antibody; CPAMD3 antibody; Complement C4-B antibody; Basic complement C4 antibody; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 antibody

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