4-Thiouracil

• Description:

  4-Thiouracil is a thionucleobase with cytostatic properties. 4-Thiouracil can be used as biological photoprobes to detect RNA structures and nucleic acid-nucleic acid contacts. 4-Thiouracil can also act as a strong ultraviolet A (UVA) photosensitizer, providing a source of the reactive oxygen species of O2. 4-Thiouracil is promising for research of photocross linking, photodamage, as well as photodynamic therapy[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H312+H332

• Target:

  Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/4-thiouracil.html

• Purity:

  99.98

• Solubility:

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(N1)NC=CC1=S

• Molecular Formula:

  C4H4N2OS

• Molecular Weight:

  128.15

• Precautions:

  H302+H312+H332

• References & Citations:

  [1]Zou X, et al. Photophysical and photochemical properties of 4-thiouracil: time-resolved IR spectroscopy and DFT studies. J Phys Chem B. 2014 Jun 5;118 (22) :5864-72.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [591-28-6]