2-Thiouracil

• Description :

  2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a Ki value of 20 μM. 2-Thiouracil antagonizes BH4-induced nNOS dimerization. 2-Thiouracil is also an antithyroid compound and a highly specific melanoma detector. 2-Thiouracil stimulates the growth of pea and corn root segments[1][2][3].

• Product Name Alternative :

  Thiouracil

• UNSPSC :

  12352005

• Hazard Statement :

  H351

• Target :

  NO Synthase

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Endocrinology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/2-thiouracil.html

• Purity :

  99.91

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |H2O : 0.67 mg/mL (ultrasonic)

• Smiles :

  O=C(C=CN1)NC1=S

• Molecular Formula :

  C4H4N2OS

• Molecular Weight :

  128.16

• Precautions :

  H351

• References & Citations :

  [1]Palumbo, A., et al. 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485 (2-3) : p. 109-12.|[2]Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39 (26) : p. 5192-201.|[3]Woodstock L, et al. The effect of 2-thiouracil on the growth of cells in the root. Annals of Botany, 1963, 27 (3) : 403-414.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NNOS

• CAS Number :

  [141-90-2]