Products for Research Use Only
RegisterLogin

THZ531

CAT: 0804-HY-103618-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-103618-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
THZ531 is a selective and covalent inhibitor of both CDK12 and CDK13 with IC50s of 158 nM and 69 nM, respectively[1].
CAS Number
1702809-17-3
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/THZ531.html
Purity
99.86
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
ClC(C(C1=CNC2=CC=CC=C12)=N3)=CN=C3N[C@@H]4CCCN(C(C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5)=O)C4
Molecular Formula
C30H32ClN7O2
Molecular Weight
558.07
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Zhang T, et al. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat Chem Biol. 2016 Oct;12 (10) :876-84.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12; CDK13; CDK7; CDK9

Related Products

CatalogName
HY-80013-01THZ1
HY-128867-01Bio-THZ1
HY-19988-01THZ1-R
HY-80013A-01THZ1 (Hydrochloride)
HY-80013B-01(E/Z) -THZ1 (dihydrochloride)

Alternative Products

CatalogName
MBS5750438THZ531
A17036-25THZ531 25mg
A17036-10THZ531 10mg
A17036-5THZ531 5mg
A17036-2THZ531 2mg
A17036-500THZ531 500mg
A17036-1THZ531 1mg
A17036-100THZ531 100mg
A17036-50THZ531 50mg
A17036-10mM-DTHZ531 10mM * 1mL in DMSO

Popular Products