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KDM5-C70

CAT: 0804-HY-120400-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120400-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels[1][2].
CAS Number
1596348-32-1
UNSPSC
12352005
Hazard Statement
H225, H319
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kdm5-c70.html
Purity
98.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(CNCC(N(CCN(C)C)CC)=O)=NC=C1)OCC
Molecular Formula
C17H28N4O3
Molecular Weight
336.43
Precautions
H225, H319
References & Citations
[1]Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12 (7) :539-45.|[2]Blair LP, et al. KDM5 lysine demethylases are involved in maintenance of 3'UTR length. Sci Adv. 2016 Nov 18;2 (11) :e1501662.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM5

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